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During diamide treatment, mitochondria remained polarized until approximately 20 minutes of diamide exposure, at which point m began to heterogeneously depolarize

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Emerging evidence implicates programmed necrosis (necroptosis), pyroptosis (gasdermin-D pore formation) and ferroptosis (lipid peroxidation driven by iron accumulation) as additional contributors, implying multiple, drug-specific death executors [72, 79, 84,85,86]