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Additionally, TMAO increases tissue factor (TF) production, which promotes thrombogenic activity and vascular senescence characterized by decreased cell migration and proliferation, while simultaneously increasing cell permeability by decreasing levels of the zonula occludens-2 (ZO-2), occluding, and vascular endothelial cadherin (VE-cadherin) proteins via the aforementioned inflammatory pathways [50]
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Licensed, NICE-recommended alternatives for weight management include semaglutide (Wegovy) and orlistat
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