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This autoimmune disorder is characterized by an irregular immune response to ingested gluten, a protein present in wheat, barley, and rye, which damages the small intestine and manifests in gastrointestinal symptoms and systemic health problems such as anemia and osteoporosis (1)

Affinity purification and mass spectrometry analysis have shown that Erastin interacts with voltage-dependent anion channel 2 (VDAC2) (103), reducing the permeability of VDAC2 to the reduced form of nicotinamide adenine dinucleotide (NADH), altering its ion selectivity, and disrupting mitochondrial respiratory chain oxidative phosphorylation (104)

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Hepatology 78 , 11061117 (2023)