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(3) Clinical Validation: Large-scale, well-designed clinical trials are urgently needed to evaluate the safety and efficacy of ferroptosis-targeting strategies (e.g., deferiprone, novel inhibitors) in COPD patients, ideally using biomarker-driven patient selection (e.g., based on MDA, 4-HNE, or GPX4 activity levels)

40 The concomitant use of TCM for HU is gaining traction due to its ability to impact various signaling pathways and UA transporters, promoting balanced inflammatory interactions and UA excretion

In patients with obesity, there is no evidence for metabolic benefits of GH therapy in the absence of true GHD (153)