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Second, given that the activation of GSR and TXNRD1 are involved in ROS elimination, if the LCS3-triggered lethality of VRK2-KO PC cells could be attributed to inhibiting the activity of both GSR and TXNRD1, then the level of ROS generated by LCS3 should have been much higher than those produced by the treatment of the TXNRD1 inhibitor auranofin

Then other excipients including isotonic agent, pH balancing agent, and preservative are also incorporated to form uniform solution

This multi-pathway approach to reducing inflammation is far more effective than relying on a single compound, especially in cases of chronic or widespread inflammation