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The peptides degrade in gastric acid and interstitial proteases before reaching systemic circulation

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Meanwhile, excessive NO co-transmission can be induced by toxic forms of both amyloid and tau, which in turn both remodels neurotransmission and amplifies nitrogen stress in ways that can feed into AD pathology (Wang et al., 2023)

The primary target would be the annulus fibrosus, which is the tough outer ring that tears during a herniation