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In support of these findings are the results from a systematic review that focused on studies conducted in India, where the prevalence of vitamin B 12 deficiency among pregnant women is up to 70 % and is considered one of the highest in the world (Reference Behere, Deshmukh and Otiv125)

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Functional experiments further showed that overexpression of PAX5, one of the genes upregulated in T2D, led to reduced insulin secretion, suppression of mitochondrial respiration, and disruption of energy balance through regulation of downstream genes such as BARX1, NEFL, PCOLCE2, and SFRP1 ( via an alternative SQSTM1 p62-mediated pathway, the levels of which are also elevated (Marques et al., 2022)