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doi: 10.1016/S0197-4580(02)00120-3

When skin is intact, resident epidermal stem cells are committed to their differentiation programs

The inflammasome inflammatory cascade may be further intensified by HIF-1 feed-back loops with cytokines like IL-6, which is upregulated in proinflammatory conditions and with HIF-1 stabilization (Xing and Lu, 2016)