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Indeed, hormone influence over BDNF expression has been demonstrated in gonadectomized female and male rats, showing decreased BDNF mRNA levels in the hippocampus that can be rescued after estradiol supplementation (Singh et al., 1995

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Durability of Cognitive Behavioral Therapy Effects for Youth and Adolescents With Anxiety, Depression, or Traumatic Stress:A Meta-Analysis on Long-Term Follow-Ups