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These MRI techniques, in combination, may be used to measure lung ventilation and/or perfusion ( Hyperpolarized noble gas MRI allows for the visualization of the gas distribution in vivo , and is sensitive to the transitional and respiratory zones of the lung ( 3 He or 129 Xe act as inhaled contrast agents, providing three-dimensional images with increased spatial and temporal resolution as compared to other functional imaging methods such as PET ( 133 Xe scintigraphy ( 129 Xe was approved by the US FDA for clinical use ( Oxygen-enhanced 1 H MRI is a research technique that relies on the weak paramagnetic properties in oxygen, which decreases the longitudinal relaxation time (T1) of tissues, thus increasing the signal ( 2 as a contrast agent, the presence and/or absence of ventilation may be evaluated and specific ventilation may be quantified ( Free-breathing 1 H MRI is also mainly a research tool which can be used to evaluate pulmonary ventilation and perfusion without the need for an endogenous contrast agent
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