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We were exploring ways of developing peptides that bind selectively, and we were very successful at that, but then we confronted the problem that our short, 23-residue peptides are not promising therapeutic candidates primarily because they cannot get into cells, Keating says

Understanding appropriate candidates helps ensure both safety and likelihood of meaningful results

Y.MesriM.et al

10 Discussion Cancer is the leading cause of death and immunotherapy has attracted a wide range of attention due to its advantages such as durable response, long-term survival benefit, and lower toxicity and side effects (242, 243), in which immune cells are the target cells for immunotherapy, which as part of the TME are mainly composed of TAMs, DCs, NK cells, TANs, MDSCs and T cells