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The findings that CIPp-18 under serum-enriched condition associated preferentially with albumin and its uptake is significantly inhibited at low temperature indicated toward the involvement of albumin-mediated uptake of CIPp-18 via facilitated diffusion

Freeze-thaw cycles cause irreversible peptide structural damagea single freeze-thaw event can reduce GHK-Cu potency by 2030%, making refrigeration (not freezing) the correct storage protocol for reconstituted solutions