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It may be relevant when remodeling occurs under metabolic strain, including GLP-1 use, caloric deficit, chronic fatigue, or age-related NAD+ decline

However, basal levels of phase I and most phase II drug metabolizing enzymes in HepG2 cells are very low compared to human hepatocytes (Wilkening et al., 2003

J.VestweberD.et al (2017)

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