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It is estimated that blood pressure issues account for over 40 million doctor visits each year (1)

Inhibition of LDHA/lactylation (oxamate) or PDGFR (axitinib) suppressed malignant phenotypes and slowed PDX growth, with the combination producing the strongest tumor regression and reduced pulmonary metastasis, supporting co-targeting of lactylation and PDGFR in VHL-mutant ccRCC [97]