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2.5 Model Predictions Because of substantial log-normal within-individual variability, standard computation of reference subject simulations, as well as population predictions and weighted residuals reported by the nonlinear mixed-effects modelling software (NONMEM) are poor measures to reflect data

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For instance, IGF-1 is made in the liver, hence an undiagnosed precancerous liver disease could have prevented the liver from producing normal levels of IGF-1. The study demonstrates the power of using population-level approaches to assess the extent to which risk factors apply across the entire cancer spectrum

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