, NNMT , 2 , ,
Data / Specifications Compound Specifications 62 H 98 N 16 O 22 Amino Acid Sequence Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val Synonyms Body Protection Compound-157, Bepecin, PL 14736, PL-10 Research Applications Context / Research Interacts with multiple signaling pathways including the NO system, FAK-paxillin pathway, VEGF expression, and growth hormone receptor expression
High selectivity for GH release with minimal impact on other hormones (ACTH, cortisol, prolactin) [1] [3]
In fact, NO at high levels inhibits heme insertion in hemoglobin, NO synthases, and heme thiolate enzymes, such as cytochrome P450s (CYP) in different manners (i.e., through the direct binding to the heme iron or to covalent modifications in heme transfer proteins) [147,148,149]