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Mechanisms underlying mitochondrial quality control include inhibition of ROS production within mitochondria, a decrease in the accumulation of abnormal proteins, and prevention of iron-induced cell death

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For the identification of druggable targets, we considered three classes of enzymes: tier-1 targets, tier-2 targets, and other enzymes. Tier-1 targets correspond to enzymes whose knockout impedes viral replication while having a minimal impact on the simulated cellular viability