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Our DIA-MS proteomics analysis of early ring-stage parasites demonstrated that several proteins involved in the parasite respiratory chain, a known source of reactive oxygen species (ROS) 49 , are downregulated in parasites with PfK13 mutations, and since GSH scavenges ROS 23 , less ROS could contribute to the elevated GSH levels in these resistant parasites

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The 3-methylglutaconyl-CoA hydratase enzyme possesses both RNA-binding and hydratase activities accounting for the name of the gene encoding this enzyme, AU RNA-binding methylglutaconyl-CoA hydratase (AUH)