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Because cellular repair takes time, the benefits of improved insulin sensitivity and mitochondrial biogenesis may not be immediately obvious

The peptide enhances expression of key transcription factors including Lhx2 and Sox9 essential for hair follicle stem cell maintenance and activation while modulating Wnt/-catenin signalinga critical pathway for hair follicle morphogenesis and cyclingwith treated follicles showing enhanced -catenin nuclear localization and increased Wnt target gene expression

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The included articles were assessed based on seven aspects: random sequence generation, allocation concealment, blinding of participants and personnel, blinding of outcome assessment, incomplete outcome data, selective reporting and other bias (Figs 2 and 3)